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Home Behavior Research Products Rodent Shockers


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Rodent Shockers

Cerebral seizures, preferably in mice, are produced using constant sinusoidal alternating current to determine the effect of anticonvulsant drugs. For the reliable induction of seizures it is necessary to achieve satisfactory current flow. Eye electrodes and (especially in mice) ear electrodes are used for this purpose. The ear electrodes offer the advantage that the course of the seizure can be observed more clearly, but have the disadvantage of a larger contact resistance. It is important that the electrodes are properly moistened! Normally the output circuit for constant current ensures the required stimulus response even for different impedances (a.c. resistances) of the animal on test. The stimulation voltage is increased inside the unit until the selected stimulation current is produced. After application the current actually used can be indicated. The stimulus duration can also be pre-set and the elapsed time is monitored on a bargraph (line of LEDs). The parameter evaluated is the percentage frequency of convulsions in a group of rodents at constant current.
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Item Listing Full Description Specifications Journal Articles
Item# Description
730105 Rodent Shocker Sine-Wave Shock Generator with Foot Switch, 115 VAC, 60 Hz
730106 Rodent Shocker Sine-Wave Shock Generator with Foot Switch, 230 VAC, 50 Hz
730107 Rodent Shocker Ear Shock Electrodes for Mice and Rats, pair
730108 Rodent Shocker Eye Shock Electrode for Mice and Rats

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Full Description Back to Top

• For testing anticonvulsant drugs
• For mice and rats
• Two types of electrodes are available: for eyes or ears
• Foot Switch operation

Cerebral seizures, preferably in mice, are produced using constant sinusoidal alternating current to determine the effect of anticonvulsant drugs. For the reliable induction of seizures it is necessary to achieve satisfactory current flow. Eye electrodes and (especially in mice) ear electrodes are used for this purpose. The ear electrodes offer the advantage that the course of the seizure can be observed more clearly, but have the disadvantage of a larger contact resistance. It is important that the electrodes are properly moistened! Normally the output circuit for constant current ensures the required stimulus response even for different impedances (a.c. resistances) of the animal on test. The stimulation voltage is increased inside the unit until the selected stimulation current is produced. After application the current actually used can be indicated. The stimulus duration can also be pre-set and the elapsed time is monitored on a bargraph (line of LEDs). The parameter evaluated is the percentage frequency of convulsions in a group of rodents at constant current.
The stimuli produced are not without danger to the operator; with an open output circuit (no animal connected to the unit) the stimulation voltage at stage 3 can reach its maximum of 750 Volt. In order to ensure operator safety the stimulus can only be triggered when two separate buttons ‘RELEASE’ (unblocking the inhibit circuit) and ‘START‘ are operated in sequence. In addition the stimulus output is floating and has no connection to ground. The current can therefore flow only between the two electrodes! As a further safety measure the output is automatically switched off if it is not connected to an object or if the contact between electrode and tissue is interrupted during stimulation. To increase the stimulation current the CURRENT SETTING button is pressed and the control to the right of it rotated to obtain the required stimulation current. This additional measure has been introduced in order to remind the user of the increasing danger. Rubber gloves must be worn when working with the unit. A foot switch is supplied for triggering the stimulus; when working with the eye electrode one hand is used to hold the animal while the other holds the flexible forceps-shaped eye electrode. The output sockets are protected against contact. Only HSE shock electrodes with the original HSE safety banana plugs may be used. There are two types of shock stimulation electrodes for applying electric shock to mice and rats for testing anticonvulsant drugs. These are eye and ear electrodes.
The eye electrodes are bipolar. They are made from a flexible plastic ‘forceps’. Each forcep end has a stainless steel button covered by thin leather. The leather must be moistened with saline solution prior to use. Only a low shock energy is required since the eye is a highly conductive point.
The ear electrodes consist of two well-insulated nickel-plated crocodile clips. The contact points are formed by two chlorided silver discs 6 mm diameter and 1 mm thick. This type of application requires a large shock energy since the contact resistance to the tissue is relatively high even when the skin is moistened. The advantage of this method is that the mice can be raised up by the electrodes so that the convulsions can be observed closely.


Specifications Back to Top

Specifications730105730106730107730108
Stimulation Frequency50 Hz or 60 Hz according to supply frequency50 Hz or 60 Hz according to supply frequency  
Stimulus Duration0.1 sec to 9.9 sec in steps of 0.1 sec, selected after pressing a button, the selected time is indicated0.1 sec to 9.9 sec in steps of 0.1 sec, selected after pressing a button, the selected time is indicated  
OutputConstant current, fully floatingConstant current, fully floating  
Output Current0 to 300 mA, 0 to 150 mA, 0 to 100 mA depending on maximum stimulation voltage selected, the setting is made on a 10-turn potentiometer and the selected value is shown on the digital display0 to 300 mA, 0 to 150 mA, 0 to 100 mA depending on maximum stimulation voltage selected, the setting is made on a 10-turn potentiometer and the selected value is shown on the digital display  
Limitation of Maximum Stimulation Voltage250 V, 500 V, 750 V in 3 steps, selected by button250 V, 500 V, 750 V in 3 steps, selected by button  
Digital DisplayThe selected stimulation current is indicated continuously in mA, the actual current applied is shown during application and can be called up later by pushing a button, the selected stimulation time is shown on pressing the TIME button, bargraph indicatThe selected stimulation current is indicated continuously in mA, the actual current applied is shown during application and can be called up later by pushing a button, the selected stimulation time is shown on pressing the TIME button, bargraph indicat  
Power110 V, 60 Hz220 V, 50 Hz  
Height Metric150 mm150 mm*na mm*na mm
Width Metric260 mm260 mm*na mm*na mm
Depth Metric360 mm360 mm*na mm*na mm
Height English5.91 in5.91 in*na in*na in
Width English10.2 in10.2 in*na in*na in
Depth English14.2 in14.2 in*na in*na in
Weight Metric55  
Weight Metric Uomkgkg  
Weight English11 lb11 lb*na lb*na lb

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Journal Articles Back to Top

Displaying 1 to 10 of 12results for Rodent Shockers   Page 1  2 

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Document

Description

100% Login to view VT22 Rodent Ventilator.pdf
[194 KB]
Rodent Ventilator use in finding arterior wall PO2 and nitric oxide release during sympathetic vasoconstriction in the rat intestine
67% Login to view VT14 Rodent Ventilator.pdf
[440 KB]
PDMI-2 Microincubator use in Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea
49% Login to view VT30 Rodent Ventilator use in Antisense Knockdown of the Gial Glutamate Transporter GLT-1.pdf
[366 KB]
Rodent Ventilator use in Antisense Knockdown of the Gial Glutamate Transporter GLT-1
47% Login to view VT12 Small rodent ventilator use in finding chronic measurement of cardiac output in conscious mice.pdf
[184 KB]
Small rodent ventilator use in finding chronic measurement of cardiac output in conscious mice
40% Login to view VT03 Rodent Ventilator use in finding Reduced PO2 and Adenosine Formation Preserve Arteriolar Nitric Oxide.pdf
[283 KB]
Rodent Ventilator use in finding Ventilatory and metabolic responses to hypoxia in the smallest simian primate, the pygmy marmoset
39% Login to view VT12 mini 2002hs.pdf
[177 KB]
Small rodent ventilator use in finding chronic measurement of cardiac output in conscious mice
37% Login to view VT30 ventilator.pdf
[360 KB]
Rodent Ventilator use in Antisense Knockdown of the Gial Glutamate Transporter GLT-1
33% Login to view VT10 683 atr.pdf
[124 KB]
Rodent Resiprator use in finding Arteriolar reactivity and capillarization in chronically stimulated rat limb skeletal muscle post-MI
33% Login to view VT04 683.pdf
[298 KB]
Rodent Ventilator use in finding Ventilatory and metabolic responses to hypoxia in the smallest simian primate, the pygmy marmoset
31% Login to view VT03 Model 683 Ventilator.pdf
[274 KB]
Rodent Ventilator use in finding Reduced PO2 and Adenosine Formation Preserve Arteriolar Nitric Oxide
   

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