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isolated heart systems
Isolated Heart Systems Overview
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Harvard Apparatus phone 508.893.8999 toll free U.S. 800.272.2775 fax 508.429.5732 www.harvardapparatus.com
TYPICAL APPLICATIONS
Cardiology
Physiology
Pharmacology
Biochemistery
Cardiac preload and afterload
dependent studies
Low-flow/ischemia studies
Metabolic studies
Cardiolplegia recovery
Hypoxic studies
TYPICAL APPLICATIONS
Cardiology
Physiology
Pharmacology
Biochemistery
Testing vasoactive
substances
Testing cardiac rhythm
Ischemia/Reperfusion
studies
Dispersion of ventricular
repolarization
Cardiovascular screening
Hypoxic studies
TYPICAL APPLICATIONS
Cardiology
Physiology
Pharmacology
Biochemistery
Testing vasoactive
substances
Ischemia / Reperfusion
studies
Testing cardiac rhythm
Dispersion of ventricular
repolarization
Cardiovascular screening
Hypoxic studies
DISADVANTAGES
Usually higher cost
Since flow is not constant, ef-
fective dose is difficult to cal-
culate
DISADVANTAGES
Non physiological mode
Heart does only
Isovolumetric work
Risk of massive pressure
may cause heart damage
ADVANTAGES
Heart produces pressure
volume work
Ultimate physiological mode
No risk of isolated heart
damaging by unintentionally
high pressure
Allows study of cardiac
function and metabolism
ADVANTAGES
Lower cost
Simple methodology
usually employed in
compound screening
ADVANTAGES
Physiological mode
No risk of damaging heart by
unintentionally high
pressure
Most commonly use
method, facilitates
comparison w/large body
of literature
DISADVANTAGES
Heart does only
Isovolumetric work
Can involve higher cost
Since flow is not constant
effective dose is difficult to
calculate
Perfusion Modes
Constant Pressure Perfusion
Constant Flow Perfusion
Langendorff Perfusion
Mode
Ejecting Working
Heart