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isolated heart systems
29
Harvard Apparatus phone 508.893.8999 toll free U.S. 800.272.2775 fax 508.429.5732 www.harvardapparatus.com
IH-SR Isolated Heart for Small Rodents
Mouse, Rat and Guinea Pig
Isolated Heart for Small Rodents
Features and Benefits
Langendorff and Optional Working Heart Perfusion
in a Single System
Compact Design, Optimized Individually for:
Mouse, Rat or Guinea Pig
Constant Pressure or Constant Flow Perfusion in
one unit, easily switch between the two modes
Compact, doesn't require wall-installed high water
columns, suitable for hearts from hypertensive rats
(perfusion pressures up to 300 mmHg are possible)
Unique integrated small volume Aortic Block with
built-in Bubble Trap and Windkessel
Large Fully-Heated Heart Chamber
Natural physiological environment for the
isolated heart
Hearts are kept alive for hours in a very stable
physiologic environment
Easy-to-use with smooth open and closed operation
All electrodes, catheters and probes are fully
enclosed for easy access and to maintain
physiological conditions while performing the
experiments
Unique cannula design
Cannula resistance is optimized according to
Hagen-Poiseuilles physical law
Different cannula sizes available, all metal,
no fragile glass cannulae
Proprietary Mini Holders allow easy and stress-free
positioning of electrodes, catheters and probes
Applications
Treatment with Inotropic Substances
Cardiac Rhythm
Ischemia and Reperfusion
Cardiac Preconditioning
Cardiovascular Screening Performance
Phenotyping of Transgenic Animals
Compound Screening
IH-SR Aortic Block
The Aortic Block really is the core of
the IH-SR. It is the attachment point
for the heart and the central hub for
perfusion control, physiological moni-
toring and drug infusion. Over 20
years of experience, research and de-
velopment have resulted in this sys-
tem core which simply cannot be
duplicated.
advanced
research
In either Langendorff or Working Heart configuration, the IH-SR can be
outfitted as a complete Cardiac Physiology Workstation with a range of
measurement devices, signal conditioning equipment and acquisition &
analysis software to provide a superior solution for virtually any study.
What makes the IH-SR unique is the revolutionary Perspex construction which
simply cannot be matched. The use of Perspex instead of traditional glass
allows our engineers to mill the perfusion pathway directly into the solid
Perspex blocks. The result is what we call a Solid State Physiological
Perfusion Circuit (S2P2C). This patented perfusion technology ensures a
precisely repeatable non-turbulent perfusion pathway for the highest fidelity
pressure and flow measurement. This combined with the naturally excellent
thermal properties of Perspex, creates a system that allows control,
maintenance and monitoring of circulatory parameters in a way that is more
physiologically relevant than any conventional perfusion system.