background image
i
s
o
l
a
t
e
d

h
e
a
r
t

s
y
s
t
e
m
s
I
s
o
l
a
t
e
d

O
r
g
a
n

&

T
i
s
s
u
e
isolated heart systems
33
Harvard Apparatus phone 508.893.8999 toll free U.S. 800.272.2775 fax 508.429.5732 www.harvardapparatus.com
IH-5 Isolated Heart Size 5
Rat, Guinea Pig and Rabbit (contined)
Benefits and Features
Working Heart Option
Provides a Valuable Tool
for the Researcher Who
Wants to Study Cardiac
Function and Metabolism
Combines the Advantages
of an Isolated Organ
Preparation with In situ-like
Perfusion Features
It Allows a More
Comprehensive
Monitoring of
Functional Parameters,
the Calculation of the
External Heart Work and
Mechanical Efficiency,
and a Considerably
Higher Sensitivity for
Various Experimental
Manipulation
Compact Design,
Optimized for Each
Species: Rabbit, Rat,
Guinea Pig
Allows Rapid and Easy Switching Between Working
Heart and Langendorff Modes
Patented Physiological Afterload System (Starling
Resistor) Eliminates the Conventional Water
Column to Create an Afterload. The Result is Vastly
Improved Arterial Pressure Evaluation Without the
Risk of Damage to Heart Valves.
Compact, Less Space in Lab is Necessary, No High
Water Column Afterload (Afterload Pressures Up
to 300 mm Hg are Possible)
Reduced Line Resistance, Optimized to Exceed
Species Flow Producing Optimal Atrial Filling
Proprietary Patented Afterload System to Eliminate
Water Column Bouncing
Laminar Flow Lines to Improve Accuracy of Flow
Measurement
Assessment of External Heart Work Under
Adjustable Load
Modular Design to Integrate More Applications in
the Future
Small Flow Resistance and Low Dead Space Volume
for Highly Reproducible and Accurate Results
Low Volume Drug Injection Pathway
Solid State Perfusion Technology Mimics In-vivo
Perfusion and Prevents Measurement Artifact
On the Langendorff Preparation Following
Signals Can be Measured:
LVP Isovolumetric LVP or Contraction Force
PP Perfusion Pressure (aortic pressure)
CF Coronary Flow
ECG Single Lead Electrocardiogram
MAP Single Monophasic Action Potential
Multiple ECG Lead I, II, III, aVr, aVf, aVl, V1-V6
Multiple MAP Up to 8
pO
2
a / e Oxygen Partial Pressure in the Affluent/Effluent
pH pH in the Effluent
T Temperature
On the Working Heart Preparation Following
Signals Can be Measured:
PrP Preload Pressure
AoP Aortic Pressure (afterload)
LVP Left Ventricular Pressure
PV Loops LV Pressure-Volume Loops
AF Aortic Flow
CO Cardiac Output (Flow into Left Atrium)
CF Coronary Flow
ECG Single Lead Electrocardiogram
MAP Single Monophasic Action Potential
Multiple ECG Lead I, II, III, aVr, aVf, aVl, V1-V6
Multiple MAP Up to 8
pO
2
a / e Oxygen Partial Pressure in the Affluent/Effluent
pH pH in the Effluent
T Temperature
Left Atrial Block, Aortic Block and Heart Chamber Arranged for Working Heart Perfusion
advanced
research