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isolated lung systems
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Harvard Apparatus phone 508.893.8999 toll free U.S. 800.272.2775 fax 508.429.5732 www.harvardapparatus.com
IPL-1 Isolated Perfused Lung for Mouse
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Isolated Perfused Lung System
Additional Options Include:
Dedicated PLUGSYS ventilator module for
negative or positive pressure ventilation VCM
Dedicated PLUGSYS module for regular
induction of hyperinflation of the lung TCM (sigh,
augmented breath)
Transducers and amplifiers for respiratory
mechanics measurement: airflow, tracheal
pressure, thoracic chamber pressure
Transducers and amplifiers for perfusion
measurement: realtime flow, perfusion pressure,
venous pressure, temperature etc
Dedicated software PULMODYN for data
acquisition and analysis of respiratory mechanics
and perfusion
Optional connection for external ventilator (e.g.
MINIVENT for testing barotraumatic ventilation
Optional connection for supplying alternative
gas mixtures and/or aerosols during negativ
pressure ventilation
Sensor and amplifier for continuous perfusate
analysis (pO
2
, pCO
2
, pH)
Deoxygenation using membrane oxygenator of
blood or erythrocyte containing perfusion
Large choice of accessories: thermocirculator,
jacketed reservoir, holders etc
Benefits and Features
Exclusive artifical thorax chamber for isolated lung
Integrated surgery table to reduce damage
during preparation phase
Integrated changeover system for switch
between physiological negative-pressure
ventilation and simple positive-pressure
ventilation
Low flow resistance and dead space volume,
minimize perfusion artifacts
Unique built-in pneumotachometer and air
humidifier with small dead volume
Drug injection pathway built directly into
pul monary perfusate stream
Unique compensation system for vascular
transmural pressure changes and simulation of
hypertensive cardiac afterload
Applications
Studies on combined respiratory and vascular effects
Physiology:
Hypoxic vasoconstriction
Pharmacology
Action of histamine, arachidonic acid metabolites
Immunopharmacology (cytokines...)
Inhalation toxicology
Environmental toxins (ozone, sulphur dioxine...)
Biochemistery
Metabolic activity (biogenic amines,
prostacyclin, angiotensin..)
Surfactant biochemistry
advanced
research