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isolated lung systems
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Harvard Apparatus phone 508.893.8999 toll free U.S. 800.272.2775 fax 508.429.5732 www.harvardapparatus.com
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Isolated Perfused
Rabbit Lung System
Benefits and Features
Optimized temperature conditions for the isolated
lung, unique jacketed thoracic chamber
Optional operating table for non-damaging in-situ
preparation
Negative-pressure ventilation similar to in-vivo
condition or positive pressure ventilation available
Low flow resistance and dead space volume,
mini mize perfusion artifacts
Drug injection pathway built directly into pul monary
perfusate stream
Unique compensation system for vascular trans-
mural pressure changes
System dedicated option for continuous
measurement of lung weight (edema)
More measurement parameters than any other
system
Applications
Studies on combined respiratory and vascular effects
Physiology:
Hypoxic vasoconstriction
Edema formation
Pharmacology
Action of histamine, arachinodic acid metabolites
Inhalation toxicology
Environmental toxins (ozone, sulphur dioxine...)
Biochemistery
Metabolic activity (biogenic amines, prostacyclin,
angiotensin..)
Surfactant biochemistry
Additional Options Include:
Dedicated PLUGSYS ventilator module for
negative or positive pressure ventilation VCM
Dedicated PLUGSYS module for regular
induction of hyperinflation of the lung TCM (sigh,
augmented breath)
Transducers and amplifiers for respiratory
mechanics measurement: airflow, tracheal
pressure, thoracic chamber pressure
Transducers and amplifiers for perfusion
measurement: realtime flow, perfusion pressure,
venous pressure, temperature etc... (see section I)
Dedicated software PULMODYN for data
acquisition and analysis of respiratory mechanics
and perfusion
Optional connection for external ventilator (see
page section F) for testing barotraumatic ventilation
Optional connection for supplying alternative gas
mixtures and/or aerosols
Sensor and amplifier for continuous perfusate
analysis (pO
2
, pCO
2
, pH)
Deoxygenation using membrane oxygenator of
blood or erythrocyte containing perfusion
Large choice of accessories: thermocirculator,
jacketed reservoir, holders etc
The Following Signals Can be Measured:
FL Respiratory Airflow
TCP Thoracal Chamber Pressure (intrapleural pressure)
TP Tracheal Pressure
PP Perfusion Pressure
VP Venous Outflow Pressure
W Lung Weight Changes
pO
2
a/e Oxygen Partial Pressure in the Affluent/Effluent
pCO
2
a/e CO
2
Partial Pressure in the Affluent/Effluent
pH a/e pH in the Affluent/Effluent
T Temperature
The Following Parameters Can be Evaluated
Using PULMODYN:
Peak Inspiratory and Expiratory Airflow
Tidal Volume, Minute Volume
Lung Resistance, Dynamic Compliance
Vascular Resistance
Precapillary and Postcapillary Resistance
Filtration Coefficient
O
2
, CO
2
Exchange
advanced
research
IPL-4 Isolated Perfused Lung for Rabbit