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Home Isolated Perfused Rodent Mesenteric Bed System


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Isolated Perfused Rodent Mesenteric Bed System

The rat hind leg and the rabbit ear are conventional preparations for investigating the tone of blood vessels under the effect of vasoactive substances in the peripheral vascular bed, either at constant perfusion pressure or at constant flow. Both set-ups suffer from the disadvantage that the measurement is affected by early edema formation. In the rat, the mesenteric circulation receives approximately 20% of the cardiac output; its regulation may therefore contribute significantly to the systemic blood pressure and circulating blood volume. The presence of arterioles, i.e. the most important vessels in the regulation of vascular resistance, renders the mesenteric bed an important preparation for the study of vascular physiology, pathophysiology and pharmacology.
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739910 Isolated Rat Mesenteric Bed System

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• For investigating the tone of small blood vessels under the effect of vasoactive substances
• Compact arrangement
• Organ is in warm and moist environment during perfusion
• Electrical field stimulation capabilities

The rat hind leg and the rabbit ear are conventional preparations for investigating the tone of blood vessels under the effect of vasoactive substances in the peripheral vascular bed, either at constant perfusion pressure or at constant flow. Both set-ups suffer from the disadvantage that the measurement is affected by early edema formation. In the rat, the mesenteric circulation receives approximately 20% of the cardiac output; its regulation may therefore contribute significantly to the systemic blood pressure and circulating blood volume. The presence of arterioles, i.e. the most important vessels in the regulation of vascular resistance, renders the mesenteric bed an important preparation for the study of vascular physiology, pathophysiology and pharmacology.
The organ bath for the rat mesenteric bed consists of a moist chamber with cover, both water jacketed. The mesenteric tissue is placed into the moist chamber on a stainless steel mesh which also acts as anode during electrical stimulation. The superior mesenteric artery is cannulated (steel cannula) and perfused at constant flow (e.g. 5 ml/min) through a roller pump via a heat exchanger included in the moist chamber. The test drug is introduced through a separate roller pump or a syringe pump directly before the vascular bed preparation. The perfusion pressure is measured in a branch before the stainless steel cannula.
For electrical stimulation, the Mesenteric Bed is placed on a stainless steel grid and a metal clip is attached to the aorta section near the steel cannula.


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Displaying 11 to 20 of 22results for Isolated Perfused Rodent Mesenteric Bed System   Page 1  2  3 

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Description

18% Login to view VT30 ventilator.pdf
[360 KB]
Rodent Ventilator use in Antisense Knockdown of the Gial Glutamate Transporter GLT-1
16% Login to view VT12 Small rodent ventilator use in finding chronic measurement of cardiac output in conscious mice.pdf
[184 KB]
Small rodent ventilator use in finding chronic measurement of cardiac output in conscious mice
14% Login to view HS07EL 1.PDF
[162 KB]
Displacement Transducer use in Characterization of oxycotin actions in guinea-pig isolated uterin artery: The effect of pregnancy
13% Login to view HS03F3 Potassium channal inhibition in coronary arteries.pdf
[536 KB]
Force Displacemen Transducer, 5-hydroxytryptamine is a mediator of 4-aminopyridine induced contractions in porcine and human isolated coronary arteries
13% Login to view VT03 Rodent Ventilator use in finding Reduced PO2 and Adenosine Formation Preserve Arteriolar Nitric Oxide.pdf
[283 KB]
Rodent Ventilator use in finding Ventilatory and metabolic responses to hypoxia in the smallest simian primate, the pygmy marmoset
13% Login to view VT12 mini 2002hs.pdf
[177 KB]
Small rodent ventilator use in finding chronic measurement of cardiac output in conscious mice
12% Login to view HS02IS Evaluation of Skeletonized LITA.pdf
[228 KB]
Isolated Organ Set use in Intraoperative and Laboratory Evaluation of Skeletonized Versus Pedicled Internal Thoracic Artery
12% Login to view HS04 latex balloon.pdf
[76 KB]
Latex Balloon use in finding Benefical Effect of Glucose on Short-Term, Perfusion-Pressure Induced Changes of Contractile Efficiency in Isolated Rabbit Hearts
11% Login to view VT21 Ligation of bronchial artery in sheep attenuates early pulmonary changes following exposure to smoke.pdf
[183 KB]
Rodent Ventilator use in finding arterior wall PO2 and nitric oxide release during sympathetic vasoconstriction in the rat intestine
11% Login to view VT10 683 atr.pdf
[124 KB]
Rodent Resiprator use in finding Arteriolar reactivity and capillarization in chronically stimulated rat limb skeletal muscle post-MI
   

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Displaying 1 to 2 of 2results for Isolated Perfused Rodent Mesenteric Bed System  

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Description

100% Login to view Isolated Preamplifier.pdf
[126 KB]
Isolated Preamplifier manual
90% Login to view VT0168 1.PDF
[229 KB]
2,3-Butanedione Monoxime Cardioplegia: Advantages Over Hyperkalemia in Blood-Perfused Isolated Hearts
   

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