Our isolated Langendorff and Working Heart systems are designed to create the nearest physiological environment possible by incorporating solid state physiological perfusion circuit (S2P2C) technology for stable, temperature-controlled laminar flow. Our patented membrane afterload resistor allows for precise peripheral afterload adjustment in working heart perfusions without the need for high water columns that incur excessive stress on the aortic valve. Most options utilize a large heart chamber allowing for a variety of sensors (ECG, Monophasic Action Potential, Pacing, LVP, Temperature) to be precisely placed within the chamber. Systems are available for species from mouse to pig.
The HSE Isolated Perfused Lung (IPL) systems are renowned for their precision German engineering with impeccable attention to all details making these systems not only able to reproduce the physiological environment (reference from IL 2 and IL1 manuals, uhlig), but also compact compared to traditional tubing and lattice systems. Options for positive and subatmospheric* (negative) pressure ventilation, alternative gas supply manifolds, constant flow/constant pressure options, nebulizer integration*, and more, we can configure a lung perfusion system meeting your unique research requirements.
*on most models
Other Isolated Organs
Whether your needs are for basic isolated liver physiology/hepatocyte isolation or isolated kidney systems or more specialized perfusion systems, chances are we can help you. Our special application systems include:
Mesenteric Bed with Stimulation
Hindlimb Perfusion with Integrated In SituForce Measurement
Full Intestinal Perfusion with Built-In Weight Measurement/Edema Monitor
Ileum Peristaltic Reflex for Guinea Pig Intestine
Perfusion Bath for Tubular Organ Segments
As with all HSE perfusion systems, care is taken to create a solution that is reproducibly by minimizing both inter-user variability and inter-system variability inherent in traditional tubing and lattice systems.