Easy to use and large back-lighted screen
Stand alone system, no PC needed
Fit to rats and mice with a simple change of grip accessories
Multi-units display: Kgs, grams, lbs., Newtons...
The grip strength meter allows the study of neuromuscular functions in rodents by determining the maximum force displayed by an animal. This test is included in the Functional Observational Battery (FOB) to screen for neurobehavioral toxicity. In this context, changes in grip strength are interpreted as evidence of motor neurotoxicity.
Basically, the grip strength meter is positioned horizontally and the subjects are held by the tail and lowered towards the apparatus. The animals are allowed to grasp the metal grid or triangular pull bar and are then pulled backwards in the horizontal plane. The force applied to the grid or to the bar just before it loses grip is recorded as the peak tension. This force can be measured in Kilograms, Grams, Pounds or Newtons
output is carried out through RS-232, printer, or chart recorder.
Depending on the grid type used, grip strength can be measured from the front or hind paws.
Ling N et al. (2007) Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat. Pain 128(3): 225-234. (rat, France)
Rouaux C et al. (2007) Sodium Valproate Exerts Neuroprotective Effects In Vivo through CREB-Binding Protein-Dependent Mechanisms But Does Not Improve Survival in an Amyotrophic Lateral Sclerosis Mouse Model . The Journal of Neuroscience, May 23, 2007 27(21):5535Ð5545 5535. (Mouse, France)
Senegal Y et al. (2007) Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice. Journal of Neurochemistry 102 (6), 1928Ð1940. (mouse, Switzerland)
Davies JE (2006) Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. Human Molecular Genetics 2006 15(1):23-31. (Mouse, UK)
Davies JE, Wang L, Garcia-Oroz L, Cook LJ, Vacher C, O'donovan DG, Rubinsztein DC (2005) Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice. Nat. Med., 11(6):672-7. (mice, UK)
Vacher C et al. (2005) Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease. Hum. Mol. Gen. 14(22): 34-3433. (mouse, UK)