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Home Microincubation / Microinjectors Microincubators Patch Slice Microincubators


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Patch Slice Microincubators

The Patch Slice Micro-Incubator System provides a complete solution to the challenge of electrophysiological study of synaptic slice connections at physiological temperatures using low noise whole cell patch recording either with or without water immersion of the microscope objective in the recording medium.
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Item# Description
650044 PSMI Patch Slice Micro-Incubator with PS-CSD
650109 Copper Cooling Tube for PSMI

For local pricing, contact your nearest distributor.



Full Description Back to Top

• Small entry angles ideal for patch slice recordings
• Shallow fluid level minimizes pipette capacitance
• Heats & Cools
• ~5 to 50C
• Peltier heat pump
• Maintains cell conditions for hours

The Patch Slice Micro-Incubator System provides a complete solution to the challenge of electrophysiological study of synaptic slice connections at physiological temperatures using low noise whole cell patch recording either with or without water immersion of the microscope objective in the recording medium.

This micro-incubator is a shallow, annular assembly which surrounds the central slice holding dish. Room temperature perfusant is delivered to the incubator which in turn delivers it to the dish at a precisely controlled temperature you select. The perfusant is removed (via user supplied suction) by an included, height adjustable aspirator (LU-ASP). Two independent channels of perfusant flow through the PSMI into the chamber via replaceable plastic tubing of low volume (<100 l) to allow rapid switching of media via an upstream valve for pharmacological studies. A separate gas inlet provides temperature controlled gas across the dish. The TC-202A provides temperature control (~5 to 50C) using the micro-incubator warming/cooling plate as the control point. Lower temperatures (approximately 10C below ambient) may be obtained by using an optional cooling tube. The cover slip dish (PS-CSD) consists of two 22 mm diameter cover slips held in a circular frame. The slice sits on the top cover slip with the immersion objective reaching the fluid surface. The bottom cover slip prevents condensation for optimal illumination and viewing. To enable placement of the patch electrode, entry angles as small as 15 can be achieved for slice access.


Specifications Back to Top

Specifications650044650109
ModelPSMI 
CertificationsCE 
Height Metric17 mm*na mm
Height English0.67 in*na in
Weight Metric0.5 kg*na kg
Weight English17.9 oz*na oz
Diameter Metric152 mm*na mm
Diameter English6 in*na in
Chamber OptionsPS-CSD Cover Slip Dish 
Temperature Range Metric5-10C below ambient to 50C without water cooling 
Temperature Stability Metric0.2C with TC-202A, at 37C with 1 ml/min perfusion 
Temperature Gradient Across Chamber2C with 1.5 ml media volume, 1 ml/min 
Built-in Temperature SensorThermistor type: 100 k? at 25C YSI 44011 
Peltier Device Current Rating6 A maximum 
Media Perfusion RatesUp to 3.0 ml/min*na ml/min

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Journal Articles Back to Top

Displaying 1 to 9 of 9results for Patch Slice Microincubators  

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Document

Description

100% Login to view WR15 PC501A Patch Clamp.pdf
[193 KB]
Patch Clamp Amplifier use in Activation of calcium entry in human carcinoma A431 cells
48% Login to view OT04.pdf
[609 KB]
A new planar multielectrode array for extracellular recprding: application to hippocampal acute slice
38% Login to view Effect of GABA on GnRH Neurons Switches from Depolarization.pdf
[262 KB]
Effect of GABA on GnRH Neurons Switches from Depolorization to Hyperpolarization at Puberty in the Female Mouse
38% Login to view OT10 captubes 2002.pdf
[262 KB]
Effect of GABA on GnRH Neurons Switches from Depolorization to Hyperpolarization at Puberty in the Female Mouse
30% Login to view Activation of calcium entry in human carcinoma.pdf
[199 KB]
Patch Clamp Amplifier use in Activation of calcium entry in human carcinoma A431 cells
28% Login to view WR18 PC501A .pdf
[150 KB]
Patch Clamp Aplifier use in finding Plasma Membrane Calcium Channels in Human Carcinoma A431 Cells
26% Login to view Plasma Membrane Calcium Channels in Human Carcinoma.pdf
[177 KB]
Patch Clamp Aplifier use in finding Plasma Membrane Calcium Channels in Human Carcinoma A431 Cells
23% Login to view LACK OF RESPONSE SUPPRESSION FOLLOWS REPEATED VENTRAL TEGMENTAL CANNABINOID ADMINISTRATION.pdf
[333 KB]
Lack of response suppression follows repeated ventral tegmental cannabinoid administration: An In Vitro Electrophysiological Study
19% Login to view Kainate Receptor Activation.pdf
[878 KB]
AMPA Kainate Receptor Activation Mediates Hypoxic Oligodendrocyte Death and Axonal Injury in Cerebral White Matter
   

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Manuals Back to Top

Displaying 1 to 1 of 1result for Patch Slice Microincubators  

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Document

Description

100% Login to view MicroIncubator PSMI.pdf
[121 KB]
PSMI Patch Slice Micro Incubator Manual
   

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