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Home Behavior Research Products Analgesia Meters Hot Plate Analgesia Meters


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Hot Plate Analgesia Meters

The LE7406 Hot-Plate performs rapid and precise screening of analgesic drug properties on small-laboratory animals according to the ‘hot-plate test’. The animal's pain sensitivity alterations induced by a specific experimental context change and/or genetic manipulations can also be evaluated through this method.
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Item# Description
760113 Hot Plate Thermal Analgesia Meter, includes SeDaCom Software

For local pricing, contact your nearest distributor.



Full Description Back to Top

• Digital set point
• Built-in electronic timer
• Foot switch timing operation
• Computer interface

The LE7406 Hot-Plate performs rapid and precise screening of analgesic drug properties on small-laboratory animals according to the ‘hot-plate test’. The animal's pain sensitivity alterations induced by a specific experimental context change and/or genetic manipulations can also be evaluated through this method.

The hot-plate test, initially described by N.B. Eddy and D. Leimbach (1953), evaluates thermal pain reflexes due to footpad contact with a heated surface. During the experiments, the animal is confined in a removable clear acrylic cylinder where the latency time to the first hind paw or/and jumping responses are measured.

In the LE7406 Hot-Plate, a thick aluminium plate (10 mm) provides a high temperature stability and even surface distribution. The plate temperature can be held at a set point between 45 and 62ºC (± 0.1ºC) by multiple proportional feedback circuits that minimize overshoot. A built-in timer activated by an external foot switch allows precise measurement of reaction time (0.1 sec precision). A remote foot-switch controls the test start/stop allowing rapid hands-free experiments. The operator can read the animal reaction time from the display or from a PC computer using the SeDaCom software. Trial number, plate temperature and reaction time are then sent to the PC through a RS-232 port.

Citations
Camarasa J et al. (2006) Association of caffeine to MDMA does not increase antinociception by potentiates adverse effects of this recreational drug. Brain Res. 1111:72-82. (mouse, Spain)
Grillet N et al. (2005) Generation and characterization of Rgs4 mutant mice. Mol. Cell. Biol. 25(10): 4221-4228. (mice, France)
Kim EJ et al. (2005) Safety pharmacology of sibutramine mesylate, an anti-obesity drug. Hum. Exp. Toxicol. 24(3): 109-119. (Rat, South Korea)
Feria MM et al. (2003) Coexistence of Two Distinct Diurnal Rhythms in Latency of Licking and Jumping Responses in Mice Hot Plate Tests. Biological Rhythm Res. 29(3):260 đ 271 (Mice, Spain)
Shaheen HM et al. (2000) Effect of Psidium guajava leaves on some aspects of the central nervous system in mice. Phytotherapy Res. 14(2):107-111 (Mice, United Arab Emirates)


Specifications Back to Top

Specifications760113
Model NumberLE7406
Computer RequirementsWindows 95, 98, ME, NT, 2000, and XP
Catalog PagesG26
Material CompositionClear Methacrylate (animal holder), and aluminum (plate)
Maximum Number of Stations1 per computer (multiple sets availble by request)
Power Requirements110/220V, 50/60Hz
CertificationCE
SeDaCom IncludedYes
Reaction Time3 digits, 0.01 sec increments
Operating Temperature45 to 62í C, 0.1 steps
Cylinder Depth200 mm
Cylinder Height250 mm
Plate Depth200 mm
Base Width200 mm
Base Depth300 mm
Base Height110 mm

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Journal Articles Back to Top

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A catalytic antibody against cocaine prevents cocaineÉs reinforcing and toxic effects in rats
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Peristaltic pump use in finding Improvements to parallel plate flow chambers to reduce reagent and cellular requirements
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Forensic Sample Processing using a Robotic Workstation
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Kringle 5 of Human Plasminogen Induces Apoptosis of Endothelial and Tumor Cells through Surface-Expressed Glucose-Regulated Protein 78
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Interspecies differences in plasma protein binding of MS-275, a novel histone deacetylase inhibitor
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In Vitro Assessment of Plasma Protein Binding and Metabolic Stability of PTK 0796 (BAY 73-6994)
   

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Manuals Back to Top

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Tail Flick Analgesia Meter Manual
   

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