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Home Behavior Research Products Analgesia Meters Rat Paw Pressure


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Rat Paw Pressure

The Randall & Selitto test is based on determination of the animal threshold response to pain induced in the paw by the application of a uniformly increasing pressure.

In the LE7306 paw-pressure, a stimulation unit allows the gradual increase (at selectable rates) of the pressure applied on the animal paw. The pressure increase is achieved by a step-motor inducing the progressive advancement of a sliding support with a distal conic tip (1 mm diameter).

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Item Listing Full Description Specifications Journal Articles Manuals
Item# Description
760234 Rat Paw Pressure Analgesia Meter, Including SeDaCom Software

For local pricing, contact your nearest distributor.



Full Description Back to Top

• Digital display
• Pressure increasing rate adjustment
• Computer interface
• Foot switch control

The Randall & Selitto test is based on determination of the animal threshold response to pain induced in the paw by the application of a uniformly increasing pressure.

In the LE7306 paw-pressure, a stimulation unit allows the gradual increase (at selectable rates) of the pressure applied on the animal paw. The pressure increase is achieved by a step-motor inducing the progressive advancement of a sliding support with a distal conic tip (1 mm diameter).

The conic tip is mounted on an extensiometric load cell, making possible the visualization on the digital display of the current force applied at each moment of the test (grams). The motor and tip units are mounted on a pivoting stand preventing any excess pressure on the animal paw.

The Control Unit makes possible the adjustment of the force transducer, balance and reset, as well as the selection of the step-motor current speed.

A remote foot-switch controls the motor turn on/off allowing rapid hands-free experiments. An automatic system is activated once the distal extreme of the sliding support track is reached or when the pedal is released at the test ending point. Then, the motor reverse its rotation at its higher speed, sliding up the conic tip again.

SeDacom software supplied with the unit can be used to automatically record the results on a PC through a RS-232 port.

Citations
Célérier E et al. (2006) Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase. Anesthesiology 104(3): 546-555. (Paw-pressure, Mice, Spain)
Célérier E et al. (2004) Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase C-gamma gene. Neuropharmacol. 46:264-272. (Tail-pressure, Mice, Spain)
Martin M et al. (2003) Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones Eur. J. .Neurosci. 17(4):701 (Tail-pressure, Mice, Spain)
Kim HW et al. (2002) The antinociceptive properties of Ethylacetate extracts from Bang-Poong (Radix Ledebouriellae) on the FreudŐs Adjuvant-Induced Arthristis in Rats. J. Vet. Sci. 3(4): 343-9. (Rats, South Korea).
Kwon YB et al. (2002) The water-soluble fraction of bee venom produces antonociceptive and anti-inflammatory effects on rheumatoid arthritis in rats. Life Sciences 71: 191-204 (Rats, South Korea)
Kwon YB et al. (2001) Bee venom injection into an acupuncture point reduces arthritis associated oedema and nociceptive responses. Pain 90 (2001) 90(3):271-80 (Rats, South Korea)
Lee JH et al. (2001) Bee venom pretreatment has both an antinociceptive and anti-inflammatory effect on carrageenan-induced inflammation. J Vet Med Sci. 63(3):251-9. (Rats, South Korea)


Specifications Back to Top

Specifications760234
Model NumberLE7306
Computer RequirementsWindows 95, 98, ME, NT, 2000, and XP
Catalog PagesG33
Material CompositionMethacrylate
Maximum Number of Stations1 per computer (multiple sets availble by request)
Power Requirements110/220V, 50/60Hz
CertificationCE
SeDaCom IncludedYes
Control Unit Width350 mm
Control Unit Depth350 mm
Control Unit Height130 mm
Stimulation Unit Width150 mm
Simulation Unit Depth210 mm
Stimulation Unit Height166 mm
Stimuli Resolution1 gram
Maximum Stimuli999 gram

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Journal Articles Back to Top

Displaying 1 to 10 of 58results for Rat Paw Pressure   Page 1  2  3  4  5  6 

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Document

Description

100% Login to view VT31 Sickle RBC's and NOS Inhibition decrease rat cerebral blood flow.pdf
[515 KB]
Sickle RBC's and NOS Inhibition decrease rat cerebral blood flow
85% Login to view HS08 pressure transducer.pdf
[46 KB]
Pressure Transducer use in finding blood pressure and heart rate spectral changes
79% Login to view PP94 Aquaporin Deletion in Mice Reduces Intraocular Pressure and Aqueous Fluid Production.pdf
[722 KB]
Aquaporin Deletion in Mice Reduces Intraocular Pressure and Aqueous Fluid Production
46% Login to view Rapid Intermittent Movement of Axonal Neurofilaments.PDF
[743 KB]
Pressure Injector use in finding Rapid Intermittent Movement of Axonal Neurofilaments Observed by Fluorescene Photobleaching
42% Login to view PG04.pdf
[448 KB]
Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H [13C] NMR
42% Login to view PI01PL 1.PDF
[734 KB]
Pressure Injector use in finding Rapid Intermittent Movement of Axonal Neurofilaments Observed by Fluorescene Photobleaching
40% Login to view PP94 Syringe Pump.pdf
[717 KB]
Aquaporin Deletion in Mice Reduces Intraocular Pressure and Aqueous Fluid Production
38% Login to view VT06 Ventilator use in finding load as an acute determinant of end-diastolic pressure-volume relation.pdf
[200 KB]
h4Ventilator use in finding load as an acute determinant of end-diastolic pressure-volume relation010100051p
35% Login to view VT42.pdf
[153 KB]
Hemodynamic effects of 15-mm-diameter microspheres on the rat pulmonary circulation
35% Login to view OT07 Temp prob2000.pdf
[109 KB]
Platelet-activating factor modulates cardiorespiratory responses in the conscious rat
   

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Manuals Back to Top

Displaying 1 to 3 of 3results for Rat Paw Pressure  

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Document

Description

100% Login to view Model708 557081.pdf
[43 KB]
Harvard 708 Pressure Controlled Ventilator Manual
52% Login to view Inspira 557058 9.pdf
[346 KB]
Harvard Inspira Advanced Safety Ventilator Manual
51% Login to view Nanoleader Pump Series NLS110P Pressure Pump Manual.pdf
[2.2 MB]
705000 NLS110P Pump Manual
   

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