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Home Electrophysiology Products Planar Lipid Bilayer Workstation Clamp for Planar Lipid Bilayer Workstation


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Clamp for Planar Lipid Bilayer Workstation

The BC-525D is the newest version of our popular bilayer clamp amplifier. Warner Instruments is the only company to supply a high quality instrument specifically designed for research using planar lipid bilayer technology and this device forms an integral component of the BLM Workstation.
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Item# Description
640022 BC-525D Bilayer Clamp with integrating headstage, supplied with rack mount hardware and model cell. Specify line operating voltage if other than 100-130 VAC

For local pricing, contact your nearest distributor.



Full Description Back to Top

• Integrated instrumentation for Planar Lipid Bilayer recording
• Simple and integrated design
• Expanding component line
• Optional power line conditioning
• Popular data acquisition packages
• Available on-site setup and training

The BC-525D is the newest version of our popular bilayer clamp amplifier. Warner Instruments is the only company to supply a high quality instrument specifically designed for research using planar lipid bilayer technology and this device forms an integral component of the BLM Workstation.

Major improvements in this new model include:
• Reduced noise and wider bandwidth
• Improved stability
• Digital hold potential
• AutoZero function
• Digital readout of membrane capacitance
• Multi-step 4-pole Bessel filter
• Capacitance compensation circuitryIntegrating Headstage

BC-525D uses an integrating (capacitive feedback) headstage for high bandwidth, low noise recording. This design also provides the ability to cancel capacitive transients produced when applying a step voltage command to the bilayer. The hybrid circuit used in the headstage has two additional benefits: an increase in speed and a reduction in the reset glitch to less than 1 pA at 1 kHz. Reset duration is 100 s.

Hold Control
The hold control for the BC-525 has been redesigned to function entirely within the digital domain. This unique approach allows the user to make holding potential adjustments in highly reproducible and discrete steps of 1 and 10 mV, up to 200 mV. Hold potentials greater than 200 mV or step sizes greater than 10 mV can be applied at the Command Input BNC’s located on the front and rear panels of the instrument.

AutoZero
The large currents flowing through the low resistance aperture prior to bilayer formation saturates the amplifier input. Under these conditions, junction potential offsets can be easily nullified by using the new AutoZero function. Once armed, the AutoZero cycle measures and compensates for any offset potentials in the conducting pathway. Traditional manual controls remain for making small corrections or for resetting the offset potential without re-activating the AutoZero cycle.

Audio Output
The BC-525 now sports a VCO circuit providing auditory feedback during membrane formation. This feature is selectable from the front panel and an internal speaker is included. An external speaker output is provided on the instrument rear panel.
Capacitance Test
This test circuit has been completely redesigned and is used to monitor the formation of the bilayer membrane. A triangle waveform is applied to the command input and the amplitude of the resulting square wave is proportional to the membrane capacitance. When selected, the membrane capacitance is read directly from the meter.

4-Pole Bessel Filter
The filtering capacity if the instrument has been expanded to include a low pass, 4-pole Bessel filter ranging from 0.05 to 20 kHz in 1-2-5 steps. The internal filter can be bypassed for use with external filtering apparatus and allows realization of the instrument’s full 60 kHz bandwidth.
Capacitance Compensation
Large capacitance transients are cancelled using both fast (0-10 s) and slow (0-2 ms) controls. Each control provides separate adjustment of both amplitude and time constant. Maximum capacitance compensation is 500 pF.

I/O
Input and output BNC’s have been duplicated or moved to the instrument rear panel except for those requiring user interaction. Front panel BNC’s include Command Input, Vc x 10 and Im Output. Rear panel BNC’s include the headstage connecter, Im Output, Cap Sync, External Reset, Command In, and Gain and Filter telegraphs. A speaker output is also available on the rear panel.


Specifications Back to Top

Specifications640022
Noise
Bandwidth60 kHz
Input Commands: HoldDigital; 1 or 10 mV steps to 200 mV maximum
Input Commands: Command InFront and rear external input, 10 V/V (applied voltage is attenuated by 10/100/1000 at the command electrode)
Junction ZeroAutoZero or manual adjust. AutoZero lockout feature. Cycle time 1.5 s. Correction to 120 mV
AudioVCO with off switch and volume control. Internal speaker and external speaker output
Capacitance TestTriangle wave applied to command electrode. Derived membrane capacitance read from meter up to 1999 pF. Calibrated (1 mV/pF) square wave available at Im output. Cap Sync (rear panel) synchronized with input triangle wave
GainMembrane current gain selectable from 1 to 200 mV/pA in 1-2-5 steps
Filter4-pole Bessel selectable from 0.05 to 20 kHz in 1-2-5 steps, or bypassed for full amplifier bandwidth
Capcity CompensationFast (0-10 s) and slow (0-2 ms) with adjustment of amplitude and time constant for each range. Maximum compensation 500 pF
Reset: AutomaticCan be overridden by manual or external control. Reset duration is 100 s
Reset: ManualReset by pushbutton switch
Reset: External InAccepts standard TTL signal
I/O: Front Panel: Command InputBNC input up to 10 V. Attenuated by 10, 100 or 1000
I/O: Front Panel: Im OutputMembrane current scaled by amplifier gain setting
I/O: Front Panel: Vc x 10 OutputApplied command voltage x 10
I/O: Rear Panel: Im OutputMembrane current scaled by amplifier gain setting
I/O: Rear Panel: Cap SyncTTL compatible
I/O: Rear Panel: External ResetAccepts standard TTL signal
I/O: Rear Panel: Command InputBNC input up to 10 V. Attenuated by 10, 100 or 1000
I/O: Rear Panel: Gain TelegraphStepped DC voltage 2.5 to 6.0 V in 0.5 V steps for gain settings of 1 to 200 mV/pA. Gain setting + 2.0 V for bypass
I/O: Rear Panel: Filter TelegraphStepped DC voltage 0.2 to 1.8 V in 0.2 V steps for filter settings of 0.05 to 20 kHz
I/O: Rear Panel: External SpeakerRear panel RCA jack
Digital Meter: 3.5 digit LCD199.9 mV full scale
Digital Meter: Junction offset199.9 mV full scale
Digital Meter: Cap Test0 to 1999 pF
Digital Meter: Vc199.9 mV full scale
Digital Meter: Im1999 pA full scale
Power100-125 or 220-240 VAC, 50/60 Hz
Height Metric9 cm
Width Metric42 cm
Depth Metric25 cm
Height English3.5 in
Width English16.5 in
Depth English10 in
Diameter MetricCE

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Journal Articles Back to Top

Displaying 1 to 10 of 18results for Clamp for Planar Lipid Bilayer Workstation   Page 1  2 

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Document

Description

100% Login to view WR11 Oocyte Clamp Amplifier.pdf
[453 KB]
Oocyte Clamp Amplifier use in finding 4-Methylhomoibotenic Acid Activates a Novel Metabotropic Glutamate Receptor Coupled to Phosphoinostide
59% Login to view OT04.pdf
[609 KB]
A new planar multielectrode array for extracellular recprding: application to hippocampal acute slice
55% Login to view OT15HA 1.PDF
[558 KB]
Forensic Sample Processing using a Robotic Workstation
46% Login to view filtration plate.pdf
[562 KB]
Forensic Sample Processing using a Robotic Workstation
45% Login to view WR18 PC501A .pdf
[150 KB]
Patch Clamp Aplifier use in finding Plasma Membrane Calcium Channels in Human Carcinoma A431 Cells
42% Login to view Plasma Membrane Calcium Channels in Human Carcinoma.pdf
[177 KB]
Patch Clamp Aplifier use in finding Plasma Membrane Calcium Channels in Human Carcinoma A431 Cells
40% Login to view WR20 OC725C.pdf
[168 KB]
Inactivation of Kv2.1 Potassium Channels with use of Voltage-Clamp Amplifier
40% Login to view lipomat.pdf
[66 KB]
LipoPrep Instrument used in Engineering Porphyrin Encapsulated Vesicles for Metal Removal from Wastewater
35% Login to view Inactivation of Kv2.1 Potassium Channels.pdf
[183 KB]
Inactivation of Kv2.1 Potassium Channels with use of Voltage-Clamp Amplifier
32% Login to view PP129.pdf
[123 KB]
Glucose "Clamp" for measurement of whole body insulin-stimulated glucose disposal
   

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