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Home Electrometer Intracellular Amplifier IE-251A


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Electrometer Intracellular Amplifier IE-251A

The IE-251A is a moderately priced intracellular electrometer, complete with current passing capability, incorporating the same basic design as the more costly IE-210. The important features required for low noise, drift free recording from glass microelectrodes have been retained in this lower cost model. The IE-251A is easy to use and an excellent choice for the budget-conscious researcher or student teaching lab.
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Item# Description
640090 IE-251A Intracellular Electrometer
640043 2510 Replacement Headstage for IE-251A Electrometer

For local pricing, contact your nearest distributor.



Full Description Back to Top


The IE-251A is a moderately priced intracellular electrometer, complete with current passing capability, incorporating the same basic design as the more costly IE-210. The important features required for low noise, drift free recording from glass microelectrodes have been retained in this lower cost model. The IE-251A is easy to use and an excellent choice for the budget-conscious researcher or student teaching lab.

The IE-251A features a very small active headstage, essentially the same as used with the more costly IE-210. Epoxy-sealed construction affords maximum resistance to saline corrosion. Its small size and low mass permit easy mounting in a micro-positioner. The electrode holder supplied connects directly to the probe input.

The amplifier features include:
• Fixed gains are at x1 and x10.
• Capacity Compensation neutralizes input capacitance up to 50 pF.
• Junction potentials up to ±200 millivolts are nulled with the DC Position control.
• Electrode Test provides convenient electrode resistance check.
• Push button operated Buzz produces oscillations at pipette tip to facilitate cell impalement.
• Convenient Probe Test port permits fast check of amplifier performance.

Current Injection
The injection circuitry of the IE-251A allows simultaneous stimulation and recording through microelectrode resistances up to 1000 megohms in two ranges. Voltages at the Stimulus Input are converted to constant currents applied to the electrode. The steady state and transient components of the current injection artifact are nulled with the DC and transient balance controls. The corrected signal is viewed at the single-ended bridge output. Electrode resistance is read from the DC balance ten-turn dial.

Overdrive Indicators
Two visual indicators call attention to overload conditions:
• Input Overdrive is illuminated whenever the probe input voltage exceeds ±1 V, caused by either excessive current through the microelectrode or an open circuit (open or blocked electrode).
• Current Overdrive warns of excessive voltage (>50 V) applied to the Stimulus Input.

This Intracellular Electrometer is supplied with a probe. An Electrode Holder must be purchased separately based on your glass outer diameter. Also, specify line operating voltage if other than
100-130 VAC.


Specifications Back to Top

Specifications640090640043
Amplifier: Input Impedance>1011 ? shunted by 0.5 pF 
Amplifier: Noise Level(0.1 Hz to 10 kHz)*
25 µV p-p input shorted
250 µV p-p, 20 M? at input
* At x1 output.
 
Amplifier: Output Resistance100 ?*na ?
Amplifier: Gainsx1 & x10 
Amplifier: Rise Time (10 to 90%)10 µsec measured with 20 M? resistor 
Amplifier: Capacity Compensation0 to 50 pF 
Amplifier: Probe Input Voltage Range±1 V 
Amplifier: DC Positioning Range±200 mV referred to input 
Amplifier: Leakage CurrentAdjustable to zero 
Amplifier: Electrode Test1 mV/M?*na mV/M?
Buzz: Amplitude Variable0-15 V 
Buzz: Frequency Variable100 Hz to 10 kHz 
Current Injection: Bridge Balance Ranges0 to 100 M? and 0 to 1000 M? 
Current Injection: Current Injection Limit±1 V divided by electrode R or 0.5 µA, whichever occurs first 
Current Injection: Stimulus Input Resistance3.3 k?*na k?
Current Injection: Maximum Stimulus Input±50 V 
Current Injection: Bridge Bal. Output Resistance100 ?*na ?
Current Injection: I Monitor Output Resistance1 k?*na k?
Current Injection: I Monitor Output Scale Factor1V = 50 nA 
Power Requirements100 to 130 or 220 to 240 V, 50/60 Hz, 10 VA 
Case Height Metric12.5 cm*na cm
Case Width Metric20.3 cm*na cm
Case Depth Metric25.4 cm*na cm
Probe Diameter Metric9.5 mm*na mm
Probe Length Metric6.5 cm*na cm
Probe Handle Diameter Metric6.5 mm*na mm
Probe Handle Length Metric6.5 mm*na mm
Shipping Weight Metric4.5 kg*na kg
WarrantyTwo years, parts & labor 
CertificationsCECE

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Journal Articles Back to Top

Displaying 1 to 10 of 28results for Electrometer Intracellular Amplifier IE-251A   Page 1  2  3 

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Document

Description

100% Login to view Intracellular Calcium Oscillations Signal Apoptosis.pdf
[826 KB]
PicoInjector use in Intracellular Calcium Oscillations Signal Apoptosis
70% Login to view HB07 bsc 1.pdf
[582 KB]
Intracellular Response Properties of Units in the Dorsal Cochlear Nucleus of Unanesthetized Decerebrate Gerbil
55% Login to view WR20 OC725C.pdf
[168 KB]
Inactivation of Kv2.1 Potassium Channels with use of Voltage-Clamp Amplifier
52% Login to view HS14 vent and amp.pdf
[431 KB]
Ventilator and Amplifier use in Hyperventilation Inducing release of Cytokines from Perfused Mouse Lung
50% Login to view Inactivation of Kv2.1 Potassium Channels.pdf
[183 KB]
Inactivation of Kv2.1 Potassium Channels with use of Voltage-Clamp Amplifier
45% Login to view A Protein Kinase C Site Highly Conserved in P2X Subunits.pdf
[331 KB]
OC-725B amplifier use in finding A Protein Kinase C Site
45% Login to view WR21 OC725 Amplifier.pdf
[324 KB]
OC-725B amplifier use in finding A Protein Kinase C Site
42% Login to view Activation of calcium entry in human carcinoma.pdf
[199 KB]
Patch Clamp Amplifier use in Activation of calcium entry in human carcinoma A431 cells
42% Login to view WR15 PC501A Patch Clamp.pdf
[193 KB]
Patch Clamp Amplifier use in Activation of calcium entry in human carcinoma A431 cells
42% Login to view HS14 Hyperventilation and Cytokine Release.pdf
[422 KB]
Ventilator and Amplifier use in Hyperventilation Inducing release of Cytokines from Perfused Mouse Lung
   

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Manuals Back to Top

Displaying 1 to 1 of 1result for Electrometer Intracellular Amplifier IE-251A  

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Description

100% Login to view 600123 temp amp.pdf
[75 KB]
Temperature amplifier manual
   

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