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Home IL-1 - Isolated Perfused Mouse Lung System


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IL-1 - Isolated Perfused Mouse Lung System

Most of the studies with isolated perfused lungs have been performed with lungs obtained from rats, guinea pigs, rabbits or dogs. The interaction of the immune system with the lung is currently an area of great interest. The mouse is the best characterized rodent species with respect to its immune system. Immunologic probes such as antibodies and cytokines are more widely available for mice versus other species. To facilitate studies on the interaction of the lung and the immune system, an apparatus for perfusing and ventilating mouse lungs has been developed. This apparatus is also suitable for studying the respiratory system of knock-out mice.
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739904 IL-1 - Isolated Perfused Mouse Lung System

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• Investigation of ventilation and perfusion in the isolated mouse lung
• Non-damaging in-situ preparation
• Negative-pressure ventilation similar to in-vivo condition
• Regular induction of deep inspiration (sigh, augmented breath)
• Pneumotachometer and air humidifier with small dead volume
• Continuous measurement of respiratory mechanics (tidal volume, airway resistance, dynamic compliance) and perfusate characteristics (pressure, lung vascular resistance, pO2, pH)

Most of the studies with isolated perfused lungs have been performed with lungs obtained from rats, guinea pigs, rabbits or dogs. The interaction of the immune system with the lung is currently an area of great interest. The mouse is the best characterized rodent species with respect to its immune system. Immunologic probes such as antibodies and cytokines are more widely available for mice versus other species. To facilitate studies on the interaction of the lung and the immune system, an apparatus for perfusing and ventilating mouse lungs has been developed. This apparatus is also suitable for studying the respiratory system of knock-out mice.
Ventilation
The lung is placed in the artificial thoracic chamber and ventilated at negative pressure. It is connected through the tracheal cannula to the pneumotachometer for measurement of respiratory flow. The respiration rate, the inspiratory and the end-expiratory pressure can be adjusted by separate controls (Positive ventilation using a regular Minivent ventilator is also possible).
Perfusion
The pulmonary artery is cannulated to provide perfusion. The perfusate is passed by means of a roller pump at constant flow through the heat exchanger, through a bubble trap to the pulmonary artery and finally into the lung vascular bed. The perfusate outflow is usually provided by cannulating the left atrium of the heart.


Journal Articles Back to Top

Displaying 1 to 10 of 14results for IL-1 - Isolated Perfused Mouse Lung System   Page 1  2 

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Description

100% Login to view HS14 Hyperventilation and Cytokine Release.pdf
[422 KB]
Ventilator and Amplifier use in Hyperventilation Inducing release of Cytokines from Perfused Mouse Lung
69% Login to view HS14 vent and amp.pdf
[431 KB]
Ventilator and Amplifier use in Hyperventilation Inducing release of Cytokines from Perfused Mouse Lung
52% Login to view VT36 687 Vent Mouse Cardiac Surgery 349.pdf
[782 KB]
VT36 687 Vent Mouse Cardiac Surgery
49% Login to view HS15 isolated heart app.pdf
[632 KB]
Isolated Heart Apparatus use in Myoglobin facilitating oxygen diffusion
39% Login to view VT01 2,3-Butanedione Monoxime Cardioplegia Advantages Over Hyperkalemia in Blood-Perfused Isolated Hearts.pdf
[199 KB]
2,3-Butanedione Monoxime Cardioplegia: Advantages Over Hyperkalemia in Blood-Perfused Isolated Hearts
28% Login to view HS15 Myoglobin facilitates oxygen diffusion.pdf
[631 KB]
Isolated Heart Apparatus use in Myoglobin facilitating oxygen diffusion
28% Login to view Inhibition of the Inositol Trisphosphate Receptor of Mouse Eggs.pdf
[440 KB]
Pico-Injector use in Inhibition of the Inositol Trisphosphate Receptor of Mouse Eggs and A7r5 Cells by KN-93 via a Mechanism Unrelated to Ca2 /Calmodulin-dependent Protein Kinase II Antagonism
27% Login to view VT27 683 Ventilator.pdf
[503 KB]
Critical role for CXCR2 and CXCR2 ligands during pathogenesis of ventilator-induced lung injury
23% Login to view PP93.pdf
[1.4 MB]
Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures
15% Login to view VT40.pdf
[353 KB]
Effects of monoclonal anti-PcrV antibody on Pseudomonas aeruginosa-induced acute lung injury in a rat model
   

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Manuals Back to Top

Displaying 1 to 4 of 4results for IL-1 - Isolated Perfused Mouse Lung System  

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100% Login to view Isolated Preamplifier.pdf
[126 KB]
Isolated Preamplifier manual
90% Login to view VT0168 1.PDF
[229 KB]
2,3-Butanedione Monoxime Cardioplegia: Advantages Over Hyperkalemia in Blood-Perfused Isolated Hearts
71% Login to view IH-SR Brochure.pdf
[7 MB]
Isolated Heart Perfusion System for Small Rodents IHSR IH-SR
50% Login to view Perfusion Tissue Systems Guide.pdf
[105 KB]
New BS4_K_Isolated Organ.qxd
   

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