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Home Isolated Perfused Rodent Mesenteric Bed System


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Isolated Perfused Rodent Mesenteric Bed System

The rat hind leg and the rabbit ear are conventional preparations for investigating the tone of blood vessels under the effect of vasoactive substances in the peripheral vascular bed, either at constant perfusion pressure or at constant flow. Both set-ups suffer from the disadvantage that the measurement is affected by early edema formation. In the rat, the mesenteric circulation receives approximately 20% of the cardiac output; its regulation may therefore contribute significantly to the systemic blood pressure and circulating blood volume. The presence of arterioles, i.e. the most important vessels in the regulation of vascular resistance, renders the mesenteric bed an important preparation for the study of vascular physiology, pathophysiology and pharmacology.
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739910 Isolated Rat Mesenteric Bed System

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• For investigating the tone of small blood vessels under the effect of vasoactive substances
• Compact arrangement
• Organ is in warm and moist environment during perfusion
• Electrical field stimulation capabilities

The rat hind leg and the rabbit ear are conventional preparations for investigating the tone of blood vessels under the effect of vasoactive substances in the peripheral vascular bed, either at constant perfusion pressure or at constant flow. Both set-ups suffer from the disadvantage that the measurement is affected by early edema formation. In the rat, the mesenteric circulation receives approximately 20% of the cardiac output; its regulation may therefore contribute significantly to the systemic blood pressure and circulating blood volume. The presence of arterioles, i.e. the most important vessels in the regulation of vascular resistance, renders the mesenteric bed an important preparation for the study of vascular physiology, pathophysiology and pharmacology.
The organ bath for the rat mesenteric bed consists of a moist chamber with cover, both water jacketed. The mesenteric tissue is placed into the moist chamber on a stainless steel mesh which also acts as anode during electrical stimulation. The superior mesenteric artery is cannulated (steel cannula) and perfused at constant flow (e.g. 5 ml/min) through a roller pump via a heat exchanger included in the moist chamber. The test drug is introduced through a separate roller pump or a syringe pump directly before the vascular bed preparation. The perfusion pressure is measured in a branch before the stainless steel cannula.
For electrical stimulation, the Mesenteric Bed is placed on a stainless steel grid and a metal clip is attached to the aorta section near the steel cannula.


Journal Articles Back to Top

Displaying 1 to 10 of 22results for Isolated Perfused Rodent Mesenteric Bed System   Page 1  2  3 

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Description

100% Login to view VT22 Rodent Ventilator.pdf
[194 KB]
Rodent Ventilator use in finding arterior wall PO2 and nitric oxide release during sympathetic vasoconstriction in the rat intestine
59% Login to view VT01 2,3-Butanedione Monoxime Cardioplegia Advantages Over Hyperkalemia in Blood-Perfused Isolated Hearts.pdf
[199 KB]
2,3-Butanedione Monoxime Cardioplegia: Advantages Over Hyperkalemia in Blood-Perfused Isolated Hearts
56% Login to view HS15 isolated heart app.pdf
[632 KB]
Isolated Heart Apparatus use in Myoglobin facilitating oxygen diffusion
34% Login to view VT14 Rodent Ventilator.pdf
[440 KB]
PDMI-2 Microincubator use in Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea
32% Login to view HS14 Hyperventilation and Cytokine Release.pdf
[422 KB]
Ventilator and Amplifier use in Hyperventilation Inducing release of Cytokines from Perfused Mouse Lung
25% Login to view HS14 vent and amp.pdf
[431 KB]
Ventilator and Amplifier use in Hyperventilation Inducing release of Cytokines from Perfused Mouse Lung
24% Login to view VT30 Rodent Ventilator use in Antisense Knockdown of the Gial Glutamate Transporter GLT-1.pdf
[366 KB]
Rodent Ventilator use in Antisense Knockdown of the Gial Glutamate Transporter GLT-1
23% Login to view HS15 Myoglobin facilitates oxygen diffusion.pdf
[631 KB]
Isolated Heart Apparatus use in Myoglobin facilitating oxygen diffusion
21% Login to view PP93.pdf
[1.4 MB]
Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures
20% Login to view VT03 Model 683 Ventilator.pdf
[274 KB]
Rodent Ventilator use in finding Reduced PO2 and Adenosine Formation Preserve Arteriolar Nitric Oxide
   

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Manuals Back to Top

Displaying 1 to 2 of 2results for Isolated Perfused Rodent Mesenteric Bed System  

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Description

100% Login to view Isolated Preamplifier.pdf
[126 KB]
Isolated Preamplifier manual
90% Login to view VT0168 1.PDF
[229 KB]
2,3-Butanedione Monoxime Cardioplegia: Advantages Over Hyperkalemia in Blood-Perfused Isolated Hearts
   

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