Fast evaluation of antidepressive, psychotropic drugs
Up to 6 mice at the same time
Automatic measurement of immobility of suspended mouse
Capable of automatic randomization
Reanalysis enhanced, immobility threshold can be readjusted
Direct exportation of the results into Excel®
Calculates energy and power in motion
The automatic tail-suspension test allows a fast and reliable screening of the psychotropic properties (anti-depressants, sedatives) of drugs.
Basically, the measuring principle is based on the energy developed by mice trying to escape from their suspension. During the test, the movements of the mice are analyzed in terms of force, energy and power developed over time.
The system includes the suspension cages (3 mice per cage) and a user-friendly software to run, record, analyze and replay the experiments. The results are either printed or stored in .txt or.xls files formats.
Alexandre C et al. (2006) Early Life Blockade of 5-Hydroxytryptamine 1A Receptors Normalizes Sleep and Depression-Like Behavior in Adult Knock-Out Mice Lacking the Serotonin Transporter. J. Neurosci. 26(20): 5554-5564. (mouse, France, Germany)
Cryan J et al. (2004) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci. Biobehav. Rev. 29(4-5):571-625. (mouse, Switzerland)
Mombereau C et al. (2004) Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior. Neuropsychopharmacol. 29:1050-1062 (mouse, Stwitzerland)
Strekalova T et al. (2004) Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming and Exploration. Neuropsychopharmacol., 29(11):2007-17 (mouse, Germany).